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Quality processes

MATRACELL® decellularization technology

Applications for soft tissue reinforcement in the dermis and wound treatment.

What do we know about soft tissue remodeling?
  • Tissue matrices or scaffolds provide a collagen structure for tissue remodeling, whereas viable cell excision seeks to minimize or prevent an inflammatory or immune response *.
  • The more compatible the donor’s Extracellular Matrix (ECM) with the receptor ECM, the less likely adverse reactions, such as inflammation, in the receptor *.
  • Chronic wounds are characterized by broken or damaged ECM that can not assist in wound healing. Treatment strategies designed to replace ECM can be beneficial *.
  • The ideal acellular matrix is one that closely approximates the structure and function of the native ECM that it is replacing *.

*International consensus. Acellular matrices for wound treatment. A review by a group of experts. London: Wounds International, 2010.

The goal is an ECM designed to...
  • Provide a biocompatible matrix.
  • Resembling an ECM extracellular matrix native to a human.
  • Support cell activity for rapid tissue regeneration.
  • Maintain inherent biomechanical properties.
  • Reduce the likelihood of infection.
  • Minimize preparation time.

How is a “biohazard” tissue that closely resembles native ECM designed to act as a biological modulator that can influence biological processes such as wound healing or soft tissue?

Use of human dermal matrix

Challenge: The human dermis contains donor cells that can elicit an immune response at the receptors and interfere with proper healing and regeneration.

Solution: Decellularization.

What is decellularization?

Removal of the donor cells of the tissue.

  • Extraction of human dermal cells / DNA.
  • Absence of intact cells documented by immunohistochemistry.
  • Absence of nuclear material documented by histology.

What are the steps?

Step One - Unlocking

To remove allograft donor cells N-Lauroylsarcosinate (N-Lauroyl sarcateate, NLS) is used as an anionic, non-denaturing detergent. To extract DNA from the donor, Benzonase® (a recombinant endonuclease) is used to efficiently degrade DNA without involving the risk associated with other endonucleases, such as prion diseases.

Step Two - Rinse
A process in which USP-grade normal saline is used, where the reactive residues of the decellularization and the donor cell remnants are removed from the allograft.
Step Three - Preservation

The processed allograft is preserved with LifeNet Health’s patented glycerol USP solution and USP saline solution. This allows the decellularized dermis to be stored at room temperature.

Step Four - Sterilization
This final step involves the use of a low dose of gamma radiation performed at ultra low temperatures. The final allograft has a Sterility Assurance Level (SAL) of 10-6.

Demonstration of biocompatibility

MATRACELL® decellularization technology

  • Offers a biocompatible matrix
  • It resembles the native ECM
  • Supports cellular activity
  • Maintains its biomechanical profile
  • Reduces the chances of infection
  • It is convenient and easy to use


MATRACELL® is the patented technology that allows the Decellularized Dermis to be Biocompatible.

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